Study of the Structural and Magnetic Properties of COFE2O4 Nanoparticles for Therapeutic Agent for Cancer Therapy
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Abstract
The cobalt ferrite ( CoFe 2 O 4 ) nanoparticles were synthesized by chemical coprecipitation technique and characterized by X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), vibrating sample magnetometer (VSM) , and Mössbauer spectroscopy. The CoFe 2 O 4 nanoparticles coated with biocompatible chitosan at different concentrations to produce homogeneous suspensions were also characterized by dynamic light scattering (DLS) and hyperthermia set-up. XRD data of the sample explored the particle size near about 7 nm in as-dried condition. TEM micrograph of bare CoFe 2 O 4 nanoparticles provided the particle size nearly too about 8 nm which is in good agreement with the XRD data. This particle size after coating with chitosan became 14 nm . EDX results of this sample confirmed its nano dimension with spinel structure. VSM results of the sample in as-dried condition showed the ferromagnetic character which has been beyond proved by Mössbauer spectroscopy. The hydrodynamic diameter (H d ) and polydispersity index (PDI) of the chitosan-coated samples also provided promising results. The samples were tested for their induction heating properties with an RF magnetic field of 20 mT and a frequency of 342 kHz . We also studied therapeutic efficiency in-vitro on 9 L gliosarcoma cancer cells, which revealed > 98% of mortality through hyperthermia protocol with the same RF field and frequency using chitosan-coated CoFe 2 O 4 nanoparticles.
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